This project developed and tested new ways of designing and analyzing clinical trials so that they are more efficient by needing fewer participants and less resources.
Two different methods of increasing efficiency were developed:
Ouyang, Y., Xu L., Karim M.E., Gustafson P., Wong H. CRTpowerdist: An R package to calculate attained power and construct the power distribution for cross-sectional stepped-wedge and parallel cluster randomized trials. Computer Methods and Programs in Biomedicine, Vol 208, 2021. https://doi.org/10.1016/j.cmpb.2021.106255
Ouyang, Y. Increasing the efficiency of pragmatic trials using innovative designs and analyses (T). University of British Columbia, 2021. https://open.library.ubc.ca/collections/ubctheses/24/items/1.0396685
Ouyang, Y., Karim, M.E., Gustafson, P. et al. Explaining the variation in the attained power of a stepped-wedge trial with unequal cluster sizes. BMC Med Res Methodol 20, 166 (2020). https://doi.org/10.1186/s12874-020-01036-5
Wong H., Ouyang Y., Karim M.E. The randomization-induced risk of a trial failing to attain its target power: assessment and mitigation. Trials. 2019 Jun 17;20(1):360. https://doi.org/10.1186/s13063-019-3471-8